Scott Pilgrim vs. The World: The Game is a licensed brawler from Ubisoft that's based on the film/comic book of the same name. It features top-notch fluid pixel art and a phenomenal chiptune soundtrack from the band Animanaguchi. Its gameplay is very similar to River City Ransom, as you fight enemies with simple yet evolving movesets and then collect coins to upgrade your character's stats and buy items in stores. It has unprecedented level designs such as a movie set, a rock show, and a huge Halloween party.
Check out Paul Robertson, the lead artist for this game. He creates pixel art animations of stunning scope and quality.
The music for this game was composed and performed by a real band, Animanaguchi. They're known to have hacked Guitar Hero controllers that they perform with.
Scott Pilgrim is my favorite modern brawler. Although I'm not crazy about its RCR-style gameplay, it's still fairly solid and can put up a serious challenge. The pixel art and music are unbelievably excellent and elevate the game to "instant classic" status in my book. It has a ton of humorous references to other brawlers as well.